Cruxpoint Health Breakthrough Initiative


The Truth About Overweight & Obesity

Enough pain, shame, frustration, and judgment. You can lose the weight you hate. Here’s the truth.


Overweight & Stuck, Part 1

Dr. Gary V. Koyen, Ph.D.  |  March 2021

Why can't I lose weight and keep it off?

Never have so many people tried so heroically to accomplish a simple personal goal—losing weight and keeping it off. Never have so many people failed. Millions of people have suffered the shame and pain of being overweight and failing at weight loss. Millions yo-yo—repeatedly taking weight off and then putting it back on. Obesity is now the number one source of self-shame.

What in the world is going on here? We have been told to “Eat Less, Move More.” “Reduce your calories and exercise more.” So we’re fat because we eat too much food (gluttony) and are too lazy to be active (sloth)? Is it really true that over 100 million people are weak-willed—and therefore fat? Well, that is the judgment that’s leveled at fat people: “It’s your own fault.” Is it really true that these millions are fat because of gluttony and sloth? Is being fat really a failure of willpower?

The answer is no. If you’re among the many who have tried and failed, at best you’ve been badly misinformed. At worst you’ve been lied to, and are being lied to. The truth is that millions of people—making heroic efforts—have proven that the “Eat less, Move More” model of weight loss does not work. 

Being overweight or obese is the new normal.

We are living sick in a world of material abundance.   

We reached this state of affairs in just the last 50 years. This is a modern phenomenon. The environment we’ve created is making us fat and sick: 40% of us are obese; 70% are overweight. As fat people we are vulnerable to disease, disability, and premature death. How did this happen? How did so many of us become overweight or obese?

The information needed for losing weight and keeping it off is known, but it’s buried in a mass of conflicting and wrong information and outright propaganda.   

Once you understand how people get fat, and why they remain fat, you can apply that knowledge to your own life and circumstances—and your genetic make-up. You can lose the weight, keep it off, and achieve a good, healthy, attractive body composition.

To succeed we must have an honest understanding of what causes the problem, and what will actually solve it. We need to know specifically what it is about our modern life and environment that is making us fat. And we need to know specifically how to reverse it.

Why does “eat less, move more” result in failure?

Eat Less, Move More fails for several reasons. First, added exercise does not cause weight loss. Added exercise is a good and healthy thing to do, and it can improve our body composition and basal metabolism, but it has a tiny effect on weight. Second, when we reduce and restrict calories our bodies adjust in off-setting ways. Our metabolism slows down significantly and we simply burn fewer calories. The fewer the calories we consume, the lower our metabolism adjusts downward. Nevertheless it’s true that if we starve ourselves we will lose weight, so calorie-restriction can work in the short run.

The failure rate using this weight loss model is estimated at 95%.   

But then why do we always put the weight back on? The answer is NOT that we return to gluttony and sloth.

The cause and the cure

The answer is in our hormones, and this is the key to the puzzle.

  • There is a set of hormones that govern our energy use and fat storage.
  • It’s hormones that cause us to become fat.
  • It’s hormones that allow us to lose weight and keep it off.
  • When these hormones are out of balance it is impossible to lose weight and keep it off.
  • All permanent weight-loss and body composition solutions require getting our hormones back into proper balance.

Without fixing the hormone problem, we will be fat for life.  

The dominant hormones


Insulin has many actions in our bodies. It regulates blood sugar, causes glucose transport into the cells of our bodies, stimulates growth, causes salt to be held, and causes fat storage. When insulin is elevated it causes fat storage regardless of what and how much we eat.


Ghrelin is our primary hunger hormone; it stimulates appetite. It also stimulates the release of growth hormones, increases food intake, and contributes to fat storage. On a calorie-restricted diet ghrelin increases, causing hunger, and it remains elevated over a year after stopping the calorie-restricted diet. Ghrelin is one of the causes of rapid weight gain—the yo-yoing—that so often follows weight loss.


Leptin is considered one of our satiety (fullness) hormones, but it plays other roles. Leptin’s primary role is to keep fat stores at an appropriate level. Leptin helps alter food intake and control energy expenditure over the long term. Leptin has a profound effect when (1) levels of the hormone fall or (2) our bodies become insensitive to leptin. This stimulates appetite and increased food intake, making it very hard to lose weight and keep it off.

Thyroid hormones

Thyroid hormones, triiodothyronine (T3) and thyroxine (T4), help regulate weight, energy levels, internal temperature, and more.

Satiety hormones

Satiety hormones: The gut hormones that stimulate satiety (fullness) include cholecystokinin (CCK), Oxyntomodulin (OXM), Peptide YY (PYY), and pancreatic polypeptide (PP). If these hormones are dampened or suppressed, the result is hunger and over-consumption of calories, leading to weight gain.

When one or more of the following are true it will be difficult to impossible to lose weight and keep it off: (1) insulin is elevated, (2) the body is insensitive to insulin, (3) ghrelin is elevated, (4) the body is insensitive to leptin, (5) the thyroid is underperforming, and/or (6) the satiety hormones are no longer fully functioning.

The solution

There is a solution that is stunningly simple and works for virtually everyone: 

Restore the hormones to proper balance and functioning.  

The focus needs to be on the hormones, not the number of calories consumed or hours spent exercising. Until the hormones are restored to good balance and functioning, losing weight is a losing battle.

The solution is a 4-pronged approach:

Measure the most important hormone levels

Measure the most important biomarkers

Make the changes that cause the hormones to return to balance and to become fully functioning.

Make the changes that cause stored fat to be burned for energy.

Insulin is the most critical hormone in the mix.  

Elevated insulin will cause fat deposition—no matter what or how much you eat. Even when eating small amounts of food insulin will force some calories into fat storage. It’s a losing game. Lowering insulin levels and restoring insulin sensitivity in the body are the absolutely essential factors for losing weight and keeping it off.

Learn more about the solution:

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